GS-441524 is a plasma metabolite of the antiviral prodrug remdesivir that has a half-life of 24 hours in humans. It has been found to be effective in fighting off feline coronavirus strains, responsible for the lethal disease feline infectious peritonitis (FIP), in in vitro tests.
FIP is caused by an immune defect or deficiency which causes white blood cells to replicate the virus as opposed to fighting it. Those cats whose immune system is not able to fight the virus, develop into wet FIP, while those who have a partial immune response develop dry FIP.
GS441524 is a nucleoside analog that acts as an alternative substrate and chain terminator. In simple terms, it interrupts the chain reaction of the virus, stopping its replication. This powerful nucleoside is proving to be a promising drug in combating this deadly infection in cats.
| Parameter | Value |
|---|---|
| Specification | 20mg/mL, 30mg/mL |
| Product Shelf Life | 1 Year |
| Product Form | Injections |
| Product Packaging | 10 Vial Per Box |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
| Product Usage | Cat FIPV Treatment |
| Product Type | Liquid |
| Test Method | HPLC UV |
| Molecular Weight | C12H13N5O4 |
| Product Storage | Store In A Cool, Dry Place |
| Product Name | GS441 FIP Treatment |
| Product Characteristics | Cat FIP, Remdesivir intermediate |
Feline Infectious Peritonitis (FIP) is a fatal viral disease in cats caused by a mutation of the feline coronavirus (FCoV). While most cats infected with FCoV do not develop FIP, in some cases, the virus mutates and triggers an abnormal immune response, leading to FIP.
FCoV is common in multi-cat environments like shelters and catteries. The virus is primarily transmitted through fecal-oral contact, where cats ingest the virus from contaminated surfaces, litter boxes, or grooming each other.
FIP manifests in two main forms: wet (effusive) and dry (non-effusive).
Packing: 1 box * 10 vials
Recommended treatment: 12 weeks.
Recommended dosage:*DOSAGE IS BASED ON THE WEIGHT AND SYMPTOMS*
Ascites / pleural effusion: 0.5mL/kg * body weight kg + 0.1 residue
FIP(Wet):0.4mL/kg * body weight kg + 0.1 residue
FIP(Dry): 0.6mL/kg * body weight kg + 0.1 residue
Eye / nerve entry: 0.7mL/kg * body weight kg + 0.1 residue
Recurrence: 0.9 mL/ kg * body weight kg + 0.1 residue
Storage
Store at room temperature or Store at 2~4 ° C (Better). Avoid light. Shelf life is one year.
Do not place in a sub-zero environment. Because this will result in the precipitation of active ingredients and the appearance of crystals, thus affecting the concentration and therapeutic effect.
