GS-441524 is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
| Property | Details |
|---|---|
| CAS Number | 1191237-69-0 |
| Grade | Pharmaceutcial Grade |
| Shipping Method | Air(UPS, FedEx, TNT, EMS) Or Sea |
| Density | 1.84±0.1 G |
| Appearance | White Powder |
| Storage | Store At Cool Dry Place |
| Molecular Weight | 291.26 |
| Purity |
99.0% |
Feline Infectious Peritonitis (FIP) is a fatal viral disease in cats caused by a mutation of the feline coronavirus (FCoV). While most cats infected with FCoV do not develop FIP, in some cases, the virus mutates and triggers an abnormal immune response, leading to FIP.
FCoV is common in multi-cat environments like shelters and catteries. The virus is primarily transmitted through fecal-oral contact, where cats ingest the virus from contaminated surfaces, litter boxes, or grooming each other.
Diagnosing FIP is challenging and often involves a combination of clinical signs, laboratory tests, and ruling out other diseases. Common diagnostic steps include:
1. Blood tests: Elevated protein levels, high white blood cell count, and low albumin-to-globulin ratio.
2. Imaging: Ultrasound or X-rays to detect fluid accumulation.
3. Fluid analysis: Testing the fluid from the abdomen or chest for elevated protein levels and specific cell types.
4. Biopsy: Histopathological examination of affected tissues can provide a definitive diagnosis.
GS441524 is a medication used to treat feline infectious peritonitis (FIP). Below are the general guidelines for using GS441524 powder, but specific usage should be adjusted according to a veterinarian's instructions:
1. Dosage:
The typical dosage depends on the cat's weight and the severity of the condition. The recommended dosage is usually 4-6 mg/kg of body weight, but higher doses may be required for severe cases.
2. Preparation:
GS441524 powder needs to be dissolved in sterile water or another appropriate solvent. Preparation should be done in a clean, sterile environment to ensure the stability and effectiveness of the medication.
3. Injection:
The dissolved solution is usually administered via subcutaneous or intravenous injection. For subcutaneous injection, choose a soft skin area (such as the back or shoulder) and use a sterile syringe. Intravenous injection should be performed by a professional veterinarian.
4. Frequency and Duration:
Generally, the injection is given once daily for at least 12 weeks. During the treatment, regular blood tests and other diagnostic evaluations are necessary to monitor the treatment's effectiveness and adjust the dosage as needed.
5. Precautions:
Ensure all equipment (syringes, solvents, etc.) is sterile.
Avoid overdosing to prevent potential toxicity and side effects.
If any adverse reactions occur during treatment, contact a veterinarian immediately.
The specific method and dosage should be determined and adjusted by a veterinarian based on the cat's condition. Always consult a professional veterinarian and follow their instructions precisely when using GS441524 powder.
