GS-441524 is an antiviral compound and the primary active metabolite of Remdesivir. It has demonstrated significant efficacy in treating certain viral infections, most notably feline infectious peritonitis (FIP), a disease caused by feline coronavirus. GS-441524 has garnered considerable attention in veterinary medicine, particularly for its role in treating this condition.
The compound works by inhibiting viral replication. It targets the viral RNA polymerase enzyme, disrupting the virus's ability to replicate its genetic material, thereby slowing or halting the infection.
GS-441524 is especially notable for its use in treating what was once considered a fatal disease, feline infectious peritonitis (FIP). The antiviral tablet form has been a breakthrough in the treatment of this disease, leading to remission in many cases.
Although not officially approved as a veterinary drug, GS-441524 has been widely adopted in the veterinary community, particularly where other treatments have failed.
| Appearance | Tablets |
| GS Standard | 99.5%min |
| Content | 20mg, 40mg, 50mg and 60mg |
| Application | For CAT FIP R&D Use ONLY |
| Recommended dosage | 10 mg/kg |
Diagnosing FIP is challenging and often involves a combination of clinical signs, laboratory tests, and ruling out other diseases. Common diagnostic steps include:
1. Blood tests: Elevated protein levels, high white blood cell count, and low albumin-to-globulin ratio.
2. Imaging: Ultrasound or X-rays to detect fluid accumulation.
3. Fluid analysis: Testing the fluid from the abdomen or chest for elevated protein levels and specific cell types.
4. Biopsy: Histopathological examination of affected tissues can provide a definitive diagnosis.
Recommended dosage: 10mg/KG * body weight kg
Taking time: Both taken before and after meals is ok. It is recommended to take it at a fixed time every day.
Taking method: Take it directly. If the cat does not eat it, it can also be mixed in the feed.
Storage: Store at room temperature or Store at 2~4 ° C. Avoid light. Shelf life is one year.
Recommended treatment for 12 weeks.
1. Introduction to the drug
Ingredients: GS441524 is a nucleoside analog that works by inhibiting viral RNA polymerase.
Indications: Mainly used to treat feline infectious peritonitis (FIP), especially wet and dry FIP.
2. Usage
Dosage: The dosage is usually calculated based on the cat's weight. The general recommended dose is 4-10 mg/kg per day. The specific dosage should be adjusted by the veterinarian based on the cat's condition and response.
Dosage frequency: Usually once a day for at least 12 weeks. Severe cases may require longer treatment.
Dosage: The tablets should be fed directly to the cat or mixed into a small amount of food to ensure that they are completely swallowed.
3. Side effects
Common side effects: May include symptoms such as loss of appetite, nausea, vomiting, and fatigue.
Serious side effects: Rare, but may include abnormal liver and kidney function. Regular blood tests are required to monitor the cat's health.
4. Precautions
Regular check-ups: During treatment, it is recommended to take the cat to the veterinarian for regular check-ups to ensure that the treatment is effective and no serious side effects occur.
Storage Conditions: The tablets should be stored in a dry, cool place away from direct sunlight and high temperatures.
